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A Glucose-Triptolide Conjugate Selectively Targets Cancer Cells under Hypoxia
A major hurdle in the treatment of cancer is chemoresistance induced under hypoxia that is characteristic of tumor microenvironment. Triptolide, a potent inhibitor of eukaryotic transcription, possesses potent antitumor activity. However, its clinical potential has been limited by toxicity and water...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509213/ https://www.ncbi.nlm.nih.gov/pubmed/33083765 http://dx.doi.org/10.1016/j.isci.2020.101536 |