Cargando…

Retina Organoid Transplants Develop Photoreceptors and Improve Visual Function in RCS Rats With RPE Dysfunction

PURPOSE: To study if human embryonic stem cell–derived photoreceptors could survive and function without the support of retinal pigment epithelium (RPE) after transplantation into Royal College of Surgeons rats, a rat model of retinal degeneration caused by RPE dysfunction. METHODS: CSC14 human embr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Bin, McLelland, Bryce T., Aramant, Robert B., Thomas, Biju B., Nistor, Gabriel, Keirstead, Hans S., Seiler, Magdalene J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2020
Materias:	Retinal Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509771/ https://www.ncbi.nlm.nih.gov/pubmed/32945842 http://dx.doi.org/10.1167/iovs.61.11.34

Ejemplares similares

Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats
por: McLelland, Bryce T., et al.
Publicado: (2018)

Co-grafts of Human Embryonic Stem Cell Derived Retina Organoids and Retinal Pigment Epithelium for Retinal Reconstruction in Immunodeficient Retinal Degenerate Royal College of Surgeons Rats
por: Thomas, Biju B., et al.
Publicado: (2021)

Calpain-5 Expression in the Retina Localizes to Photoreceptor Synapses
por: Schaefer, Kellie A., et al.
Publicado: (2016)

Retinal Organoids Long-Term Functional Characterization Using Two-Photon Fluorescence Lifetime and Hyperspectral Microscopy
por: Xue, Yuntian, et al.
Publicado: (2021)

DHA Shortage Causes the Early Degeneration of Photoreceptors and RPE in Mice With Peroxisomal β-Oxidation Deficiency
por: Swinkels, Daniëlle, et al.
Publicado: (2023)

Polarized RPE Secretome Preserves Photoreceptors in Retinal Dystrophic RCS Rats
por: Ahluwalia, Kabir, et al.
Publicado: (2023)

Timed Notch Inhibition Drives Photoreceptor Fate Specification in Human Retinal Organoids
por: Chew, Shereen H., et al.
Publicado: (2022)

Helical Fasciculation of Bipolar and Horizontal Cell Neurites for Wiring With Photoreceptors in Macaque and Mouse Retinas
por: Tsukamoto, Yoshihiko, et al.
Publicado: (2021)

Transcriptomic Analysis of the Developmental Similarities and Differences Between the Native Retina and Retinal Organoids
por: Cui, Zekai, et al.
Publicado: (2020)

Retina-to-Retina Transplantation of Embryonic Donor Cells, Labelled with BrdU or Carrying a Genetic Marker
por: Aramant, Robert, et al.
Publicado: (1992)

The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction
por: Sreekumar, Parameswaran G., et al.
Publicado: (2016)

Albumen Transport to Bruch's Membrane and RPE by Choriocapillaris Caveolae
por: Nakanishi, Masataka, et al.
Publicado: (2016)

Vision Recovery and Connectivity by Fetal Retinal Sheet Transplantation in an Immunodeficient Retinal Degenerate Rat Model
por: Seiler, Magdalene J., et al.
Publicado: (2017)

Medium Depth Influences O(2) Availability and Metabolism in Human RPE Cultures
por: Hass, Daniel T., et al.
Publicado: (2023)

Deletion of Efemp1 Is Protective Against the Development of Sub-RPE Deposits in Mouse Eyes
por: Stanton, James B., et al.
Publicado: (2017)

Complement-Mediated Regulation of Apolipoprotein E in Cultured Human RPE Cells
por: Yang, Ping, et al.
Publicado: (2017)

Risuteganib Protects against Hydroquinone–induced Injury in Human RPE Cells
por: Yang, Ping, et al.
Publicado: (2020)

PGC-1α Induces Human RPE Oxidative Metabolism and Antioxidant Capacity
por: Iacovelli, Jared, et al.
Publicado: (2016)

Highly Differentiated Human Fetal RPE Cultures Are Resistant to the Accumulation and Toxicity of Lipofuscin-Like Material
por: Zhang, Qitao, et al.
Publicado: (2019)

Characterization of Human iPSC-RPE on a Prosthetic Bruch's Membrane Manufactured From Silk Fibroin
por: Galloway, Chad A., et al.
Publicado: (2018)

Conditional, Genetically Encoded, Small Molecule–Regulated Inhibition of NFκB Signaling in RPE Cells
por: Vu, Khiem T., et al.
Publicado: (2017)

Light-Induced Smooth Endoplasmic Reticulum Rearrangement in a Unique Interlaced Compartmental Pattern in Macaca mulatta RPE
por: Altera, Annalisa, et al.
Publicado: (2021)

Ultrastructural Circuitry in Retinal Cell Transplants to Rat Retina
por: Zucker, Charles L., et al.
Publicado: (1994)

Absence of Sigma 1 Receptor Accelerates Photoreceptor Cell Death in a Murine Model of Retinitis Pigmentosa
por: Wang, Jing, et al.
Publicado: (2017)

Preliminary observations on soluble programmed cell death protein-1 as a prognostic and predictive biomarker in patients with metastatic melanoma treated with patient-specific autologous vaccines
por: Dillman, Robert O., et al.
Publicado: (2019)

Sema3A Reduces Sprouting of Adult Rod Photoreceptors In Vitro
por: Kung, Frank, et al.
Publicado: (2017)

Diurnal Photoreceptor Outer Segment Renewal in Mice Is Independent of Galectin-3
por: Esposito, Nicholas J., et al.
Publicado: (2021)

Analysis of MTHFR, CBS, Glutathione, Taurine, and Hydrogen Sulfide Levels in Retinas of Hyperhomocysteinemic Mice
por: Cui, Xuezhi, et al.
Publicado: (2017)

Capn5 Expression in the Healthy and Regenerating Zebrafish Retina
por: Coomer, Cagney E., et al.
Publicado: (2018)

Spatiotemporal Coordination of RPE Cell Quality by Extracellular Vesicle miR-494-3p Via Competitive Interplays With SIRT3 or PTEN
por: Hamuro, Junji, et al.
Publicado: (2023)

Neuroretinal-Derived Caveolin-1 Promotes Endotoxin-Induced Inflammation in the Murine Retina
por: Gurley, Jami M., et al.
Publicado: (2020)

NADPH Oxidase Contributes to Photoreceptor Degeneration in Constitutively Active RAC1 Mice
por: Song, Hongman, et al.
Publicado: (2016)

Potential of Small Molecule–Mediated Reprogramming of Rod Photoreceptors to Treat Retinitis Pigmentosa
por: Nakamura, Paul A., et al.
Publicado: (2016)

Electrophysiologic Characterization of Developing Human Embryonic Stem Cell-Derived Photoreceptor Precursors
por: Schick, Revital, et al.
Publicado: (2020)

Abnormal Cone and Rod Photoreceptor Morphogenesis in gdf6a Mutant Zebrafish
por: Nadolski, Nathan J., et al.
Publicado: (2020)

Photoreceptor Degeneration Accompanies Vascular Changes in a Zebrafish Model of Diabetic Retinopathy
por: Ali, Zaheer, et al.
Publicado: (2020)

Rod Photoreceptor Neuroprotection in Dark-Reared Pde6brd10 Mice
por: Berkowitz, Bruce A., et al.
Publicado: (2020)

Phosphodiesterase Inhibitors Sildenafil and Vardenafil Reduce Zebrafish Rod Photoreceptor Outer Segment Shedding
por: Campbell, Leah J., et al.
Publicado: (2017)

Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency
por: Nagar, Saumya, et al.
Publicado: (2017)

Essential Role of XBP1 in Maintaining Photoreceptor Synaptic Integrity in Early Diabetic Retinopathy
por: McLaughlin, Todd, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_nk9lrarp5os5fks36q95kcnmnv