Oxidative pentose phosphate pathway and glucose anaplerosis support maintenance of mitochondrial NADPH pool under mitochondrial oxidative stress

Mitochondrial NADPH protects cells against mitochondrial oxidative stress by serving as an electron donor to antioxidant defense systems. However, due to technical challenges, it still remains unknown as to the pool size of mitochondrial NADPH, its dynamics, and NADPH/NADP(+) ratio. Here, we have sy...

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Detalles Bibliográficos
Autores principales: Moon, Sun Jin, Dong, Wentao, Stephanopoulos, Gregory N., Sikes, Hadley D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Research Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510474/
https://www.ncbi.nlm.nih.gov/pubmed/33005744
http://dx.doi.org/10.1002/btm2.10184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510474/
https://www.ncbi.nlm.nih.gov/pubmed/33005744
http://dx.doi.org/10.1002/btm2.10184

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