Cargando…
Oxidative pentose phosphate pathway and glucose anaplerosis support maintenance of mitochondrial NADPH pool under mitochondrial oxidative stress
Mitochondrial NADPH protects cells against mitochondrial oxidative stress by serving as an electron donor to antioxidant defense systems. However, due to technical challenges, it still remains unknown as to the pool size of mitochondrial NADPH, its dynamics, and NADPH/NADP(+) ratio. Here, we have sy...
Autores principales: | Moon, Sun Jin, Dong, Wentao, Stephanopoulos, Gregory N., Sikes, Hadley D. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510474/ https://www.ncbi.nlm.nih.gov/pubmed/33005744 http://dx.doi.org/10.1002/btm2.10184 |
Ejemplares similares
-
Consumption of NADPH for 2-HG Synthesis Increases Pentose Phosphate Pathway Flux and Sensitizes Cells to Oxidative Stress
por: Gelman, Susan J., et al.
Publicado: (2018) -
Nrf2 deficiency decreases NADPH from impaired IDH shuttle and pentose phosphate pathway in retinal pigmented epithelial cells to magnify oxidative stress‐induced mitochondrial dysfunction
por: Cano, Marisol, et al.
Publicado: (2021) -
The Entner-Doudoroff and Nonoxidative Pentose Phosphate Pathways Bypass Glycolysis and the Oxidative Pentose Phosphate Pathway in Ralstonia solanacearum
por: Jyoti, Poonam, et al.
Publicado: (2020) -
Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism
por: Perry, Rachel J., et al.
Publicado: (2016) -
Phosphoenolpyruvate Cycling via Mitochondrial Phosphoenolpyruvate Carboxykinase Links Anaplerosis and Mitochondrial GTP with Insulin Secretion
por: Stark, Romana, et al.
Publicado: (2009)