Ceruloplasmin oxidized and deamidated by Parkinson's disease cerebrospinal fluid induces epithelial cells proliferation arrest and apoptosis

In Parkinson's disease, the ferroxidase ceruloplasmin (Cp) is oxidized and deamidated by the pathological cerebrospinal fluid (CSF) environment. These modifications promote the gain of integrin binding properties, fostered by the deamidation of two NGR-motifs present in the Cp sequence that con...

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Detalles Bibliográficos
Autores principales: Barbariga, Marco, Zanardi, Alan, Curnis, Flavio, Conti, Antonio, Boselli, Daniela, Di Terlizzi, Simona, Alessio, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511351/
https://www.ncbi.nlm.nih.gov/pubmed/32968118
http://dx.doi.org/10.1038/s41598-020-72447-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511351/
https://www.ncbi.nlm.nih.gov/pubmed/32968118
http://dx.doi.org/10.1038/s41598-020-72447-z

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