Modulation of CYP2C9 activity and hydrogen peroxide production by cytochrome b(5)

Cytochromes P450 (CYP) play a major role in drug detoxification, and cytochrome b(5) (cyt b5) stimulates the catalytic cycle of mono-oxygenation and detoxification reactions. Collateral reactions of this catalytic cycle can lead to a significant production of toxic reactive oxygen species (ROS). One...

Descripción completa

Detalles Bibliográficos
Autores principales: Gómez-Tabales, Javier, García-Martín, Elena, Agúndez, José A. G., Gutierrez-Merino, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511354/
https://www.ncbi.nlm.nih.gov/pubmed/32968106
http://dx.doi.org/10.1038/s41598-020-72284-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511354/
https://www.ncbi.nlm.nih.gov/pubmed/32968106
http://dx.doi.org/10.1038/s41598-020-72284-0

Ejemplares similares