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Modulation of CYP2C9 activity and hydrogen peroxide production by cytochrome b(5)
Cytochromes P450 (CYP) play a major role in drug detoxification, and cytochrome b(5) (cyt b5) stimulates the catalytic cycle of mono-oxygenation and detoxification reactions. Collateral reactions of this catalytic cycle can lead to a significant production of toxic reactive oxygen species (ROS). One...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511354/ https://www.ncbi.nlm.nih.gov/pubmed/32968106 http://dx.doi.org/10.1038/s41598-020-72284-0 |