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Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture
Genetic association studies have identified 44 common genome-wide significant risk loci for late-onset Alzheimer’s disease (LOAD). However, LOAD genetic architecture and prediction are unclear. Here we estimate the optimal P-threshold (P(optimal)) of a genetic risk score (GRS) for prediction of LOAD...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511365/ https://www.ncbi.nlm.nih.gov/pubmed/32968074 http://dx.doi.org/10.1038/s41467-020-18534-1 |