Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons

Mutations in PRKN are the most common cause of early onset Parkinson’s disease. Parkin is an E3 ubiquitin ligase, functioning in mitophagy. Mitochondrial abnormalities are present in PRKN mutant models. Patient derived neurons are a promising model in which to study pathogenic mechanisms and therape...

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Detalles Bibliográficos
Autores principales: Schwartzentruber, Aurelie, Boschian, Camilla, Lopes, Fernanda Martins, Myszczynska, Monika A., New, Elizabeth J., Beyrath, Julien, Smeitink, Jan, Ferraiuolo, Laura, Mortiboys, Heather
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511396/
https://www.ncbi.nlm.nih.gov/pubmed/32968089
http://dx.doi.org/10.1038/s41598-020-72345-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511396/
https://www.ncbi.nlm.nih.gov/pubmed/32968089
http://dx.doi.org/10.1038/s41598-020-72345-4

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