Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility

Artemisinins have revolutionized the treatment of Plasmodium falciparum malaria; however, resistance threatens to undermine global control efforts. To broadly explore artemisinin susceptibility in apicomplexan parasites, we employ genome-scale CRISPR screens recently developed for Toxoplasma gondii...

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Detalles Bibliográficos
Autores principales: Harding, Clare R., Sidik, Saima M., Petrova, Boryana, Gnädig, Nina F., Okombo, John, Herneisen, Alice L., Ward, Kurt E., Markus, Benedikt M., Boydston, Elizabeth A., Fidock, David A., Lourido, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511413/
https://www.ncbi.nlm.nih.gov/pubmed/32968076
http://dx.doi.org/10.1038/s41467-020-18624-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511413/
https://www.ncbi.nlm.nih.gov/pubmed/32968076
http://dx.doi.org/10.1038/s41467-020-18624-0

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