β-Lapachone Induces Acute Oxidative Stress in Rat Primary Astrocyte Cultures that is Terminated by the NQO1-Inhibitor Dicoumarol

β-lapachone (β-lap) is reduced in tumor cells by the enzyme NAD(P)H: quinone acceptor oxidoreductase 1 (NQO1) to a labile hydroquinone which spontaneously reoxidises to β-lap, thereby generating reactive oxygen species (ROS) and oxidative stress. To test for the consequences of an acute exposure of...

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Detalles Bibliográficos
Autores principales: Steinmeier, Johann, Kube, Sophie, Karger, Gabriele, Ehrke, Eric, Dringen, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511478/
https://www.ncbi.nlm.nih.gov/pubmed/32789798
http://dx.doi.org/10.1007/s11064-020-03104-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511478/
https://www.ncbi.nlm.nih.gov/pubmed/32789798
http://dx.doi.org/10.1007/s11064-020-03104-0

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