Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice

Cdc42 is a small RhoGTPase regulating multiple functions in eukaryotic cells. The activity of Cdc42 is significantly elevated in several tissues of aged mice, while the Cdc42 gain‐of‐activity mouse model presents with a premature aging‐like phenotype and with decreased lifespan. These data suggest a...

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Detalles Bibliográficos
Autores principales: Florian, Maria Carolina, Leins, Hanna, Gobs, Michael, Han, Yang, Marka, Gina, Soller, Karin, Vollmer, Angelika, Sakk, Vadim, Nattamai, Kalpana J., Rayes, Ahmad, Zhao, Xueheng, Setchell, Kenneth, Mulaw, Medhanie, Wagner, Wolfgang, Zheng, Yi, Geiger, Hartmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Short Take
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511875/
https://www.ncbi.nlm.nih.gov/pubmed/32755011
http://dx.doi.org/10.1111/acel.13208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511875/
https://www.ncbi.nlm.nih.gov/pubmed/32755011
http://dx.doi.org/10.1111/acel.13208

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