Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD(+) redox

Mammals' aging is correlated with the accumulation of somatic heteroplasmic mitochondrial DNA (mtDNA) mutations. Whether and how aging accumulated mtDNA mutations modulate fertility remains unknown. Here, we analyzed oocyte quality of young (≤30 years old) and elder (≥38 years old) female patie...

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Detalles Bibliográficos
Autores principales: Yang, Liang, Lin, Xiaobing, Tang, Haite, Fan, Yuting, Zeng, Sheng, Jia, Lei, Li, Yukun, Shi, Yanan, He, Shujing, Wang, Hao, Hu, Zhijuan, Gong, Xiao, Liang, Xiaoyan, Yang, Yi, Liu, Xingguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511885/
https://www.ncbi.nlm.nih.gov/pubmed/32744417
http://dx.doi.org/10.1111/acel.13206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511885/
https://www.ncbi.nlm.nih.gov/pubmed/32744417
http://dx.doi.org/10.1111/acel.13206

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