Cargando…

Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD(+) redox

Mammals' aging is correlated with the accumulation of somatic heteroplasmic mitochondrial DNA (mtDNA) mutations. Whether and how aging accumulated mtDNA mutations modulate fertility remains unknown. Here, we analyzed oocyte quality of young (≤30 years old) and elder (≥38 years old) female patie...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Liang, Lin, Xiaobing, Tang, Haite, Fan, Yuting, Zeng, Sheng, Jia, Lei, Li, Yukun, Shi, Yanan, He, Shujing, Wang, Hao, Hu, Zhijuan, Gong, Xiao, Liang, Xiaoyan, Yang, Yi, Liu, Xingguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511885/ https://www.ncbi.nlm.nih.gov/pubmed/32744417 http://dx.doi.org/10.1111/acel.13206

Ejemplares similares

NADH/NAD(+) Redox Imbalance and Diabetic Kidney Disease
por: Yan, Liang-Jun
Publicado: (2021)

Mitochondrial NAD(+)/NADH Redox State and Diabetic Cardiomyopathy
por: Berthiaume, Jessica M., et al.
Publicado: (2019)

Sources and implications of NADH/NAD(+) redox imbalance in diabetes and its complications
por: Wu, Jinzi, et al.
Publicado: (2016)

Rapamycin maintains NAD(+)/NADH redox homeostasis in muscle cells
por: Zhang, Zhigang, et al.
Publicado: (2020)

In Vivo NADH/NAD(+) Biosensing Reveals the Dynamics of Cytosolic Redox Metabolism in Plants
por: Steinbeck, Janina, et al.
Publicado: (2020)

Neuroprotection in Glaucoma: NAD(+)/NADH Redox State as a Potential Biomarker and Therapeutic Target
por: Petriti, Bledi, et al.
Publicado: (2021)

Assessment of NADH/NAD(+) Redox Imbalance in Psoriatic Lesions Using the FMSF Technique: Therapeutic Aspects
por: Gebicki, Jerzy, et al.
Publicado: (2023)

Global Metabolic Shifts in Age and Alzheimer’s Disease Mouse Brains Pivot at NAD(+)/NADH Redox Sites
por: Dong, Yue, et al.
Publicado: (2019)

NAD(+)/NADH redox alterations reconfigure metabolism and rejuvenate senescent human mesenchymal stem cells in vitro
por: Yuan, Xuegang, et al.
Publicado: (2020)

Methotrexate use and NAD(+)/NADH metabolism in psoriatic keratinocytes
por: Liszewska, Agata, et al.
Publicado: (2020)

The effect of succinate on brain NADH/NAD(+) redox state and high energy phosphate metabolism in acute traumatic brain injury
por: Stovell, Matthew G., et al.
Publicado: (2018)

An engineered enzyme that targets circulating lactate to alleviate intracellular NADH/NAD(+) imbalance
por: Patgiri, Anupam, et al.
Publicado: (2020)

Biochemical Issues in Estimation of Cytosolic Free NAD/NADH Ratio
por: Sun, Feifei, et al.
Publicado: (2012)

Genetically encoded biosensors for evaluating NAD(+)/NADH ratio in cytosolic and mitochondrial compartments
por: Hu, Qingxun, et al.
Publicado: (2021)

The extracellular lactate-to-pyruvate ratio modulates the sensitivity to oxidative stress-induced apoptosis via the cytosolic NADH/NAD(+) redox state
por: Go, Simei, et al.
Publicado: (2020)

Investigation of NADH Binding, Hydride Transfer, and NAD(+) Dissociation during NADH Oxidation by Mitochondrial Complex I Using Modified Nicotinamide Nucleotides
por: Birrell, James A., et al.
Publicado: (2013)

The mechanism of RNA 5′ capping with NAD(+), NADH, and desphospho-CoA
por: Bird, Jeremy G., et al.
Publicado: (2016)

Tolerance to NADH/NAD(+) imbalance anticipates aging and anti-aging interventions
por: Alonso-Lavin, Alvar J., et al.
Publicado: (2021)

Insights into the inhibitory mechanisms of NADH on the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase
por: Liu, Yabing, et al.
Publicado: (2018)

Redox Specificity of 2-Hydroxyacid-Coupled NAD(+)/NADH Dehydrogenases: A Study Exploiting “Reactive” Arginine as a Reporter of Protein Electrostatics
por: Gupta, Pooja, et al.
Publicado: (2013)

In planta study of photosynthesis and photorespiration using NADPH and NADH/NAD(+) fluorescent protein sensors
por: Lim, Shey-Li, et al.
Publicado: (2020)

Toxicity of Melaleuca alternifolia essential oil to the mitochondrion and NAD(+)/NADH dehydrogenase in Tribolium confusum
por: Liao, Min, et al.
Publicado: (2018)

Investigating mitochondrial redox state using NADH and NADPH autofluorescence
por: Blacker, Thomas S., et al.
Publicado: (2016)

Cofactor engineering to regulate NAD(+)/NADH ratio with its application to phytosterols biotransformation
por: Su, Liqiu, et al.
Publicado: (2017)

Sex-related differences in human plasma NAD(+)/NADH levels depend on age
por: Schwarzmann, Luisa, et al.
Publicado: (2021)

Influence of electrode potential, pH and NAD(+) concentration on the electrochemical NADH regeneration
por: Aamer, Emad, et al.
Publicado: (2022)

Highly efficient 5' capping of mitochondrial RNA with NAD(+) and NADH by yeast and human mitochondrial RNA polymerase
por: Bird, Jeremy G, et al.
Publicado: (2018)

Correction: Redox Specificity of 2-Hydroxyacid-Coupled NAD(+)/NADH Dehydrogenases: A Study Exploiting "Reactive" Arginine as a Reporter of Protein Electrostatics
por: Gupta, Pooja, et al.
Publicado: (2016)

Regulation of NAD(+)/NADH Redox Involves the Protective Effects of Ginsenoside Rb1 against Oxygen–Glucose Deprivation/Reoxygenation-Induced Astrocyte Lesions
por: Liu, Ying, et al.
Publicado: (2023)

OPA1-Exon4b Binds to mtDNA D-Loop for Transcriptional and Metabolic Modulation, Independent of Mitochondrial Fusion
por: Yang, Liang, et al.
Publicado: (2020)

Roles of Pyruvate, NADH, and Mitochondrial Complex I in Redox Balance and Imbalance in β Cell Function and Dysfunction
por: Luo, Xiaoting, et al.
Publicado: (2015)

Imaging the NADH:NAD(+) Homeostasis for Understanding the Metabolic Response of Mycobacterium to Physiologically Relevant Stresses
por: Bhat, Shabir A., et al.
Publicado: (2016)

Tracking the Courier: In Planta Imaging of NADH/NAD(+) Ratios with a Genetically Encoded Biosensor
por: Hõrak, Hanna
Publicado: (2020)

Synthesis of [4S‐(2)H]NADH, [4R‐(2)H]NADH, [4‐(2)H(2)]NADH and [4‐(2)H]NAD(+) cofactors through heterogeneous biocatalysis in heavy water
por: Rowbotham, Jack S., et al.
Publicado: (2021)

NAD(+) Repletion Rescues Female Fertility during Reproductive Aging
por: Bertoldo, Michael J., et al.
Publicado: (2020)

Protocols for analyzing metabolic derangements caused by increased NADH/NAD(+) ratio in cell lines and in mice
por: Liu, Shanshan, et al.
Publicado: (2022)

Dysregulated NAD(H) homeostasis associated with ciprofloxacin tolerance in Escherichia coli investigated on a single-cell level with the Peredox [NADH:NAD+] biosensor
por: Urbaniec, Joanna, et al.
Publicado: (2023)

Using Fractional Intensities of Time-resolved Fluorescence to Sensitively Quantify NADH/NAD(+) with Genetically Encoded Fluorescent Biosensors
por: Chang, Mengfang, et al.
Publicado: (2017)

Cofactor Specificity Engineering of Streptococcus mutans NADH Oxidase 2 for NAD(P)(+) Regeneration in Biocatalytic Oxidations
por: Petschacher, Barbara, et al.
Publicado: (2014)

Influence of GSH synthesis inhibition on temporal distribution of NAD+/NADH during vascular endothelial cells proliferation
por: Busu, C, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_7o7rp63k2ailqjqp0ur2m2u99h