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Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico
The creation of artificial enzymes is a key objective of computational protein design. Although de novo enzymes have been successfully designed, these exhibit low catalytic efficiencies, requiring directed evolution to improve activity. Here, we use room-temperature X-ray crystallography to study ch...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511930/ https://www.ncbi.nlm.nih.gov/pubmed/32968058 http://dx.doi.org/10.1038/s41467-020-18619-x |