Osmolytes dynamically regulate mutant Huntingtin aggregation and CREB function in Huntington’s disease cell models

Osmolytes are organic solutes that change the protein folding landscape shifting the equilibrium towards the folded state. Herein, we use osmolytes to probe the structuring and aggregation of the intrinsically disordered mutant Huntingtin (mHtt) vis-a-vis the pathogenicity of mHtt on transcription f...

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Detalles Bibliográficos
Autores principales: Aravindan, Shreyaas, Chen, Samantha, Choudhry, Hannaan, Molfetta, Celine, Chen, Kuang Yu, Liu, Alice Y. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511939/
https://www.ncbi.nlm.nih.gov/pubmed/32968182
http://dx.doi.org/10.1038/s41598-020-72613-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511939/
https://www.ncbi.nlm.nih.gov/pubmed/32968182
http://dx.doi.org/10.1038/s41598-020-72613-3

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