CEP131 Abrogates CHK1 Inhibitor-Induced Replication Defects and Is Associated with Unfavorable Outcome in Neuroblastoma

Checkpoint kinase 1 (CHK1) plays a key role in genome surveillance and integrity throughout the cell cycle. Selective inhibitors of CHK1 (CHK1i) are undergoing clinical evaluation for various human malignancies, including neuroblastoma. Recently, we reported that CHK1i, PF-477736, induced a p53-medi...

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Detalles Bibliográficos
Autores principales: Ando, Kiyohiro, Cázares-Ordoñez, Verna, Makishima, Makoto, Yokoyama, Atsushi, Suenaga, Yusuke, Nagase, Hiroki, Kobayashi, Shinichi, Kamijo, Takehiko, Koshinaga, Tsugumichi, Wada, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7512061/
https://www.ncbi.nlm.nih.gov/pubmed/33014050
http://dx.doi.org/10.1155/2020/2752417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7512061/
https://www.ncbi.nlm.nih.gov/pubmed/33014050
http://dx.doi.org/10.1155/2020/2752417

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