Natural product inspired optimization of a selective TRPV6 calcium channel inhibitor

Transient receptor potential vanilloid 6 (TRPV6) is a calcium channel implicated in multifactorial diseases and overexpressed in numerous cancers. We recently reported the phenyl-cyclohexyl-piperazine cis-22a as the first submicromolar TRPV6 inhibitor. This inhibitor showed a seven-fold selectivity...

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Detalles Bibliográficos
Autores principales: Cunha, Micael Rodrigues, Bhardwaj, Rajesh, Carrel, Aline Lucie, Lindinger, Sonja, Romanin, Christoph, Parise-Filho, Roberto, Hediger, Matthias A., Reymond, Jean-Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513592/
https://www.ncbi.nlm.nih.gov/pubmed/33479695
http://dx.doi.org/10.1039/d0md00145g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513592/
https://www.ncbi.nlm.nih.gov/pubmed/33479695
http://dx.doi.org/10.1039/d0md00145g

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