Cargando…
Growth-factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development
Precise control and maintenance of population size is fundamental for organismal development and homeostasis. The three cell types of the mammalian blastocyst are generated in precise proportions over a short time, suggesting a mechanism to ensure a reproducible outcome. We developed a minimal mathe...
Autores principales: | Saiz, Néstor, Mora-Bitria, Laura, Rahman, Shahadat, George, Hannah, Herder, Jeremy P, Garcia-Ojalvo, Jordi, Hadjantonakis, Anna-Katerina |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513828/ https://www.ncbi.nlm.nih.gov/pubmed/32720894 http://dx.doi.org/10.7554/eLife.56079 |
Ejemplares similares
-
Asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst
por: Saiz, Néstor, et al.
Publicado: (2016) -
A developmental insurance policy
por: Saiz, Nestor, et al.
Publicado: (2017) -
Combinatorial chromatin dynamics foster accurate cardiopharyngeal fate choices
por: Racioppi, Claudia, et al.
Publicado: (2019) -
Rb regulates fate choice and lineage commitment in vivo
por: Calo, Eliezer, et al.
Publicado: (2010) -
Epithelial geometry regulates spindle orientation and progenitor fate during formation of the mammalian epidermis
por: Box, Kimberly, et al.
Publicado: (2019)