Low glucose enhanced metformin’s inhibitory effect on pancreatic cancer cells by suppressing glycolysis and inducing energy stress via up-regulation of miR-210-5p

To explore mechanisms underlying the discrepancy in anti-tumor effects of metformin on pancreatic cancer cells PANC-1 under different glucose conditions. We cultured PANC-1 cells in 25 mM and 5 mM glucose media, then treated with or without metformin. It showed that metformin significantly inhibited...

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Detalles Bibliográficos
Autores principales: Ma, Minglei, Ma, Chifa, Li, Pingping, Ma, Chunxiao, Ping, Fan, Li, Wei, Xu, Lingling, Zhang, Huabing, Sun, Qi, Li, Yuxiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513847/
https://www.ncbi.nlm.nih.gov/pubmed/32718270
http://dx.doi.org/10.1080/15384101.2020.1796036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513847/
https://www.ncbi.nlm.nih.gov/pubmed/32718270
http://dx.doi.org/10.1080/15384101.2020.1796036

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