Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5

HIV Nef counteracts cellular host restriction factors SERINC3 and SERINC5, but our understanding of how naturally occurring global Nef sequence diversity impacts these activities is limited. Here, we quantify SERINC3 and SERINC5 internalization function for 339 Nef clones, representing the major pan...

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Detalles Bibliográficos
Autores principales: Jin, Steven W., Mwimanzi, Francis M., Mann, Jaclyn K., Bwana, Mwebesa Bosco, Lee, Guinevere Q., Brumme, Chanson J., Hunt, Peter W., Martin, Jeff N., Bangsberg, David R., Ndung’u, Thumbi, Brumme, Zabrina L., Brockman, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515180/
https://www.ncbi.nlm.nih.gov/pubmed/32925973
http://dx.doi.org/10.1371/journal.ppat.1008813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515180/
https://www.ncbi.nlm.nih.gov/pubmed/32925973
http://dx.doi.org/10.1371/journal.ppat.1008813

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