APC-β-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis

Sporadic colorectal cancer initiates with mutations in APC or its degradation target β-catenin, producing TCF-dependent nuclear transcription driving tumorigenesis. The intestinal epithelial receptor, GUCY2C, with its canonical paracrine hormone guanylin, regulates homeostatic signaling along the cr...

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Detalles Bibliográficos
Autores principales: Blomain, Erik S., Rappaport, Jeffrey A., Pattison, Amanda M., Bashir, Babar, Caparosa, Ellen, Stem, Jonathan, Snook, Adam E., Waldman, Scott A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515458/
https://www.ncbi.nlm.nih.gov/pubmed/32037952
http://dx.doi.org/10.1080/15384047.2020.1721262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515458/
https://www.ncbi.nlm.nih.gov/pubmed/32037952
http://dx.doi.org/10.1080/15384047.2020.1721262

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