Sphingosine kinase 2 inhibitor ABC294640 suppresses neuronal excitability and inhibits multiple endogenously and exogenously expressed voltage-gated ion channels in cultured cells

Sphingolipids regulate multiple cellular processes, including proliferation, autophagy, and apoptosis. Sphingosine kinases, the key enzymes in the metabolism of sphingolipids, are overexpressed in many cancers, making them important targets for the development of antitumor drugs. ABC294640 is a sele...

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Detalles Bibliográficos
Autores principales: Zhang, Fei, Hu, Wenqi, Qu, Lili, Cang, Chunlei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515484/
https://www.ncbi.nlm.nih.gov/pubmed/32615066
http://dx.doi.org/10.1080/19336950.2020.1788364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515484/
https://www.ncbi.nlm.nih.gov/pubmed/32615066
http://dx.doi.org/10.1080/19336950.2020.1788364

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