Near-infrared-traceable DNA nano-hydrolase: specific eradication of telomeric G-overhang in vivo

Telomeric DNA, whose length homeostasis is closely correlated with immortality of cancer cells, is regarded as a molecular clock for cellular lifespan. Regarding the capacity in forming G-quadruplex, G-rich 3′-overhang (G-overhang) has been considered as an attractive anticancer target. However, it...

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Detalles Bibliográficos
Autores principales: Sun, Yuhuan, Zhao, Chuanqi, Cui, Tingting, Qin, Hongshuang, Niu, Jingsheng, Ren, Jinsong, Qu, Xiaogang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515709/
https://www.ncbi.nlm.nih.gov/pubmed/32853337
http://dx.doi.org/10.1093/nar/gkaa693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515709/
https://www.ncbi.nlm.nih.gov/pubmed/32853337
http://dx.doi.org/10.1093/nar/gkaa693

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