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Near-infrared-traceable DNA nano-hydrolase: specific eradication of telomeric G-overhang in vivo
Telomeric DNA, whose length homeostasis is closely correlated with immortality of cancer cells, is regarded as a molecular clock for cellular lifespan. Regarding the capacity in forming G-quadruplex, G-rich 3′-overhang (G-overhang) has been considered as an attractive anticancer target. However, it...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515709/ https://www.ncbi.nlm.nih.gov/pubmed/32853337 http://dx.doi.org/10.1093/nar/gkaa693 |