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Semisynthesis of site-specifically succinylated histone reveals that succinylation regulates nucleosome unwrapping rate and DNA accessibility
Posttranslational modifications (PTMs) of histones represent a crucial regulatory mechanism of nucleosome and chromatin dynamics in various of DNA-based cellular processes, such as replication, transcription and DNA damage repair. Lysine succinylation (Ksucc) is a newly identified histone PTM, but i...
Autores principales: | Jing, Yihang, Ding, Dongbo, Tian, Gaofei, Kwan, Ka Chun Jonathan, Liu, Zheng, Ishibashi, Toyotaka, Li, Xiang David |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515725/ https://www.ncbi.nlm.nih.gov/pubmed/32766790 http://dx.doi.org/10.1093/nar/gkaa663 |
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