Inducible EphA4 knockout causes motor deficits in young mice and is not protective in the SOD1(G93A) mouse model of ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron loss that ultimately leads to fatal paralysis. Reducing levels or function of the tyrosine kinase, ephrin type-A receptor 4 (EphA4), has been suggested as a potential approach for slowing disease progres...

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Detalles Bibliográficos
Autores principales: Dominguez, Sara L., Earr, Timothy, Dourado, Michelle, Ngu, Hai, Meilandt, William J., Hanson, Jesse E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515861/
https://www.ncbi.nlm.nih.gov/pubmed/32973290
http://dx.doi.org/10.1038/s41598-020-72723-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515861/
https://www.ncbi.nlm.nih.gov/pubmed/32973290
http://dx.doi.org/10.1038/s41598-020-72723-y

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