Cargando…

Blood biomarkers indicate that the preclinical stages of Alzheimer's disease present overlapping molecular features

It is still debated whether non-specific preclinical symptoms of Alzheimer’s disease (AD) can have diagnostic relevance. We followed the evolution from cognitively normal to AD by NMR-based metabolomics of blood sera. Multivariate statistical analysis of the NMR profiles yielded models that discrimi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Di Costanzo, Alfonso, Paris, Debora, Melck, Dominique, Angiolillo, Antonella, Corso, Gaetano, Maniscalco, Mauro, Motta, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515866/ https://www.ncbi.nlm.nih.gov/pubmed/32973179 http://dx.doi.org/10.1038/s41598-020-71832-y

Ejemplares similares

Exploring Airway Diseases by NMR-Based Metabonomics: A Review of Application to Exhaled Breath Condensate
por: Sofia, Matteo, et al.
Publicado: (2011)

Distinctive Pattern of Serum Elements During the Progression of Alzheimer’s Disease
por: Paglia, Giuseppe, et al.
Publicado: (2016)

A Targeted Mass Spectrometry Approach to Identify Peripheral Changes in Metabolic Pathways of Patients with Alzheimer’s Disease
por: Reveglia, Pierluigi, et al.
Publicado: (2023)

Challenges in LC–MS-based metabolomics for Alzheimer’s disease early detection: targeted approaches versus untargeted approaches
por: Reveglia, Pierluigi, et al.
Publicado: (2021)

Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia
por: Cristofano, Adriana, et al.
Publicado: (2016)

Serum Amino Acid Profiles in Normal Subjects and in Patients with or at Risk of Alzheimer Dementia
por: Corso, Gaetano, et al.
Publicado: (2017)

Metabolomic Analysis by Nuclear Magnetic Resonance Spectroscopy as a New Approach to Understanding Inflammation and Monitoring of Pharmacological Therapy in Children and Young Adults With Cystic Fibrosis
por: Montuschi, Paolo, et al.
Publicado: (2018)

CD33 rs2455069 SNP: Correlation with Alzheimer’s Disease and Hypothesis of Functional Role
por: Tortora, Fabiana, et al.
Publicado: (2022)

Cognitive indicators of transition to preclinical and prodromal stages of Alzheimer's disease in Down syndrome
por: Hartley, Sigan L., et al.
Publicado: (2020)

Altered Blood Levels of Anti-Gal Antibodies in Alzheimer’s Disease: A New Clue to Pathogenesis?
por: Angiolillo, Antonella, et al.
Publicado: (2021)

Tandem Mass Spectrometry as Strategy for the Selective Identification and Quantification of the Amyloid Precursor Protein Tyr682 Residue Phosphorylation Status in Human Blood Mononuclear Cells
por: Reveglia, Pierluigi, et al.
Publicado: (2021)

NMR Profiling of Exhaled Breath Condensate Defines Different Metabolic Phenotypes of Non-Cystic Fibrosis Bronchiectasis
por: Paris, Debora, et al.
Publicado: (2020)

Metabolomics of COPD Pulmonary Rehabilitation Outcomes via Exhaled Breath Condensate
por: Maniscalco, Mauro, et al.
Publicado: (2022)

Application of Sebum Lipidomics to Biomarkers Discovery in Neurodegenerative Diseases
por: Briganti, Stefania, et al.
Publicado: (2021)

Measuring cognition and function in the preclinical stage of Alzheimer's disease
por: Weintraub, Sandra, et al.
Publicado: (2018)

Electromagnetic signatures of the preclinical and prodromal stages of Alzheimer’s disease
por: Nakamura, Akinori, et al.
Publicado: (2018)

Biomarkers and Tools for Predicting Alzheimer’s Disease in the Preclinical Stage
por: Li, Tao-Ran, et al.
Publicado: (2022)

The Immune-Modulator Pidotimod Affects the Metabolic Profile of Exhaled Breath Condensate in Bronchiectatic Patients: A Metabolomics Pilot Study
por: D’Amato, Maria, et al.
Publicado: (2019)

Circulating levels of IL-1 family cytokines and receptors in Alzheimer’s disease: new markers of disease progression?
por: Italiani, Paola, et al.
Publicado: (2018)

A Rapid Antigen Detection Test to Diagnose SARS-CoV-2 Infection Using Exhaled Breath Condensate by A Modified Inflammacheck(®) Device
por: Maniscalco, Mauro, et al.
Publicado: (2021)

Plasma lipocalin-2 levels in the preclinical stage of Alzheimer's disease
por: Eruysal, Emily, et al.
Publicado: (2019)

Change in retinal structural anatomy during the preclinical stage of Alzheimer's disease
por: Santos, Cláudia Y., et al.
Publicado: (2018)

Brain reserve contributes to distinguishing preclinical Alzheimer’s stages 1 and 2
por: Yildirim, Zerrin, et al.
Publicado: (2023)

Decreased body mass index in the preclinical stage of autosomal dominant Alzheimer’s disease
por: Müller, Stephan, et al.
Publicado: (2017)

P‐tau235: a novel biomarker for staging preclinical Alzheimer’s disease
por: Lantero‐Rodriguez, Juan, et al.
Publicado: (2021)

Differential Abnormality in Functional Connectivity Density in Preclinical and Early-Stage Alzheimer's Disease
por: Song, Yu, et al.
Publicado: (2022)

Moving beyond disclosure: Stages of care in preclinical Alzheimer's disease biomarker testing
por: Ketchum, Fred B., et al.
Publicado: (2022)

Entorhinal Subfield Vulnerability to Neurofibrillary Tangles in Aging and the Preclinical Stage of Alzheimer’s Disease
por: Llamas-Rodríguez, Josué, et al.
Publicado: (2022)

Phosphorylated Tau 181 Serum Levels Predict Alzheimer’s Disease in the Preclinical Stage
por: Qin, Wei, et al.
Publicado: (2022)

Effects of Lippia citriodora Leaf Extract on Lipid and Oxidative Blood Profile of Volunteers with Hypercholesterolemia: A Preliminary Study
por: Angiolillo, Antonella, et al.
Publicado: (2021)

Metabolomics of blood reveals age-dependent pathways in Parkinson’s Disease
por: D’Ascenzo, Nicola, et al.
Publicado: (2022)

Toward refining Alzheimer's disease into overlapping subgroups
por: Hascup, Erin R., et al.
Publicado: (2020)

A Case of Late Stage Sebaceous Trichofolliculoma Showing Overlapping Features with Folliculosebaceous Cystic Hamartoma
por: Shin, Eun-Jae, et al.
Publicado: (2016)

Plasma 24-metabolite Panel Predicts Preclinical Transition to Clinical Stages of Alzheimer’s Disease
por: Fiandaca, Massimo S., et al.
Publicado: (2015)

Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum
por: Milà‐Alomà, Marta, et al.
Publicado: (2020)

Functional and structural alterations of dorsal attention network in preclinical and early‐stage Alzheimer's disease
por: Wu, Huimin, et al.
Publicado: (2023)

MCP-1 levels in astrocyte-derived exosomes are changed in preclinical stage of Alzheimer's disease
por: Wang, Ting, et al.
Publicado: (2023)

COVID-19 and diffusing capacity of the lungs for carbon monoxide: a clinical biomarker in postacute care settings
por: Fuschillo, Salvatore, et al.
Publicado: (2021)

Clinical Applications of Nasal Nitric Oxide in Allergic Rhinitis: A Review of the Literature
por: Marcuccio, Giuseppina, et al.
Publicado: (2023)

Prevalence and risk of progression of preclinical Alzheimer’s disease stages: a systematic review and meta-analysis
por: Parnetti, Lucilla, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_47a586vplv7fg7ltfl0tdj18kg