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Network Hamiltonian models reveal pathways to amyloid fibril formation

Amyloid fibril formation is central to the etiology of a wide range of serious human diseases, such as Alzheimer’s disease and prion diseases. Despite an ever growing collection of amyloid fibril structures found in the Protein Data Bank (PDB) and numerous clinical trials, therapeutic strategies rem...

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Detalles Bibliográficos
Autores principales: Yu, Yue, Grazioli, Gianmarc, Unhelkar, Megha H., Martin, Rachel W., Butts, Carter T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515878/
https://www.ncbi.nlm.nih.gov/pubmed/32973286
http://dx.doi.org/10.1038/s41598-020-72260-8