Inhibition of Aquaporin 4 Decreases Amyloid Aβ40 Drainage Around Cerebral Vessels

Aquaporin-4 (AQP4) is located mainly in the astrocytic end-feet around cerebral blood vessels and regulates ion and water homeostasis in the brain. While deletion of AQP4 is shown to reduce amyloid-β (Aβ) clearance and exacerbate Aβ peptide accumulation in plaques and vessels of Alzheimer’s disease...

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Detalles Bibliográficos
Autores principales: Rosu, Gabriela-Camelia, Catalin, Bogdan, Balseanu, Tudor Adrian, Laurentiu, Mogoanta, Claudiu, Margaritescu, Kumar-Singh, Samir, Daniel, Pirici
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515968/
https://www.ncbi.nlm.nih.gov/pubmed/32783141
http://dx.doi.org/10.1007/s12035-020-02044-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515968/
https://www.ncbi.nlm.nih.gov/pubmed/32783141
http://dx.doi.org/10.1007/s12035-020-02044-8

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