EpCAM-Targeted 3WJ RNA Nanoparticle Harboring Delta-5-Desaturase siRNA Inhibited Lung Tumor Formation via DGLA Peroxidation

Knocking down delta-5-desaturase (D5D) expression by D5D small interfering RNA (siRNA) has been reported that could redirect the cyclooxygenase-2 (COX-2)-catalyzed dihomo-γ-linolenic acid (DGLA) peroxidation from producing prostaglandin E2 to 8-hydroxyoctanoic acid (8-HOA), resulting in the inhibiti...

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Detalles Bibliográficos
Autores principales: Pang, Lizhi, Shah, Harshit, Wang, Hongzhi, Shu, Dan, Qian, Steven Y., Sathish, Venkatachalem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515975/
https://www.ncbi.nlm.nih.gov/pubmed/33230429
http://dx.doi.org/10.1016/j.omtn.2020.08.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515975/
https://www.ncbi.nlm.nih.gov/pubmed/33230429
http://dx.doi.org/10.1016/j.omtn.2020.08.024

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