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The Genetic Mechanisms Driving Diversification of the KIR Gene Cluster in Primates

The activity and function of natural killer (NK) cells are modulated through the interactions of multiple receptor families, of which some recognize MHC class I molecules. The high level of MHC class I polymorphism requires their ligands either to interact with conserved epitopes, as is utilized by...

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Detalles Bibliográficos
Autores principales: Bruijnesteijn, Jesse, de Groot, Natasja G., Bontrop, Ronald E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516082/
https://www.ncbi.nlm.nih.gov/pubmed/33013938
http://dx.doi.org/10.3389/fimmu.2020.582804