The Loss of Nuclear PTEN Increases Tumorigenesis in a Preclinical Mouse Model for Hepatocellular Carcinoma

The PTEN gene is highly mutated in many cancers, including hepatocellular carcinoma. The PTEN protein is located at different subcellular regions—PTEN at the plasma membrane suppresses PI3-kinase signaling in cell growth, whereas PTEN in the nucleus maintains genome integrity. Here, using nuclear PT...

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Detalles Bibliográficos
Autores principales: Kato, Takashi, Yamada, Tatsuya, Nakamura, Hideki, Igarashi, Atsushi, Anders, Robert A., Sesaki, Hiromi, Iijima, Miho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516300/
https://www.ncbi.nlm.nih.gov/pubmed/33083717
http://dx.doi.org/10.1016/j.isci.2020.101548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516300/
https://www.ncbi.nlm.nih.gov/pubmed/33083717
http://dx.doi.org/10.1016/j.isci.2020.101548

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