Increased Protein Stability and Interleukin-2 Production of a LAT(G131D) Variant With Possible Implications for T Cell Anergy

The adaptor LAT plays a crucial role in the transduction of signals coming from the TCR/CD3 complex. Phosphorylation of some of its tyrosines generates recruitment sites for other cytosolic signaling molecules. Tyrosine 132 in human LAT is essential for PLC-γ activation and calcium influx generation...

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Detalles Bibliográficos
Autores principales: Arbulo-Echevarria, Mikel M., Vico-Barranco, Inmaculada, Narbona-Sánchez, Isaac, García-Cózar, Francisco, Miazek, Arkadiusz, Aguado, Enrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517355/
https://www.ncbi.nlm.nih.gov/pubmed/33042995
http://dx.doi.org/10.3389/fcell.2020.561503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517355/
https://www.ncbi.nlm.nih.gov/pubmed/33042995
http://dx.doi.org/10.3389/fcell.2020.561503

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