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Increased Protein Stability and Interleukin-2 Production of a LAT(G131D) Variant With Possible Implications for T Cell Anergy
The adaptor LAT plays a crucial role in the transduction of signals coming from the TCR/CD3 complex. Phosphorylation of some of its tyrosines generates recruitment sites for other cytosolic signaling molecules. Tyrosine 132 in human LAT is essential for PLC-γ activation and calcium influx generation...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517355/ https://www.ncbi.nlm.nih.gov/pubmed/33042995 http://dx.doi.org/10.3389/fcell.2020.561503 |