Cargando…

Therapeutic Potential of Targeting Malt1-Dependent TCR Downstream Signaling to Promote the Survival of MHC-Mismatched Allografts

Strategies targeting T cells are the cornerstone of immunosuppression after solid organ transplantation. The transcription factor NF-κB is a key regulator of downstream T-cell activation and induction of inflammatory mediators; its full activation via antigen receptor engagement requires both the sc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Govender, Lerisa, Mikulic, Josip, Wyss, Jean-Christophe, Gaide, Olivier, Thome, Margot, Golshayan, Dela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517581/ https://www.ncbi.nlm.nih.gov/pubmed/33042160 http://dx.doi.org/10.3389/fimmu.2020.576651

Ejemplares similares

IL-2-Mediated In Vivo Expansion of Regulatory T Cells Combined with CD154–CD40 Co-Stimulation Blockade but Not CTLA-4 Ig Prolongs Allograft Survival in Naive and Sensitized Mice
por: Govender, Lerisa, et al.
Publicado: (2017)

Lipoxin A(4) Prevents the Progression of De Novo and Established Endometriosis in a Mouse Model by Attenuating Prostaglandin E(2) Production and Estrogen Signaling
por: Kumar, Rajesh, et al.
Publicado: (2014)

Differential Effects of the Mitochondria-Active Tetrapeptide SS-31 (D-Arg-dimethylTyr-Lys-Phe-NH(2)) and Its Peptidase-Targeted Prodrugs in Experimental Acute Kidney Injury
por: Wyss, Jean-Christophe, et al.
Publicado: (2019)

MHC Mismatch Inhibits Neurogenesis and Neuron Maturation in Stem Cell Allografts
por: Chen, Zhiguo, et al.
Publicado: (2011)

Key Features Relevant to Select Antigens and TCR From the MHC-Mismatched Repertoire to Treat Cancer
por: Audehm, Stefan, et al.
Publicado: (2019)

The paracaspase MALT1: biological function and potential for therapeutic inhibition
por: Jaworski, Maike, et al.
Publicado: (2015)

Atopy as an independent predictor for long-term patient and graft survival after kidney transplantation
por: Porret, Raphaël, et al.
Publicado: (2022)

MALT1 protease activity in primary effusion lymphoma
por: Juilland, Mélanie, et al.
Publicado: (2017)

A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometry
por: Singh, Nishant K., et al.
Publicado: (2022)

Role of the CARMA1/BCL10/MALT1 complex in lymphoid malignancies
por: Juilland, Mélanie, et al.
Publicado: (2016)

BTLA suppress acute rejection via regulating TCR downstream signals and cytokines production in kidney transplantation and prolonged allografts survival
por: Zhang, Jiayi, et al.
Publicado: (2019)

Holding All the CARDs: How MALT1 Controls CARMA/CARD-Dependent Signaling
por: Juilland, Mélanie, et al.
Publicado: (2018)

TCR–pMHC bond conformation controls TCR ligand discrimination
por: Sasmal, Dibyendu K., et al.
Publicado: (2019)

The Enigmatic Nature of the TCR-pMHC Interaction: Implications for CAR-T and TCR-T Engineering
por: Shevyrev, D. V., et al.
Publicado: (2022)

Author Correction: BTLA suppress acute rejection via regulating TCR downstream signals and cytokines production in kidney transplantation and prolonged allografts survival
por: Zhang, Jiayi, et al.
Publicado: (2022)

Tolerance of a Vascularized Composite Allograft Achieved in MHC Class-I-mismatch Swine via Mixed Chimerism
por: Lellouch, Alexandre G., et al.
Publicado: (2022)

TCR/pMHC Optimized Protein crystallization Screen
por: Bulek, Anna M., et al.
Publicado: (2012)

Targeting the MHC Ligandome by Use of TCR-Like Antibodies
por: Høydahl, Lene Støkken, et al.
Publicado: (2019)

Targeting cancers through TCR-peptide/MHC interactions
por: He, Qinghua, et al.
Publicado: (2019)

Search for MHC/TCR-Like Systems in Living Organisms
por: Paganini, Julien, et al.
Publicado: (2021)

Equine Herpesvirus Protein E10 Induces Membrane Recruitment and Phosphorylation of Its Cellular Homologue, Bcl-10
por: Thome, Margot, et al.
Publicado: (2001)

Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide–MHC
por: Hoerter, John A.H., et al.
Publicado: (2013)

Abstract 45: Vascularized Composite Allograft Tolerance Across A Full MHC Mismatch Is Possible With Transient High Dose Tacrolimus
por: Leto Barone, Angelo A., et al.
Publicado: (2017)

Limitations for TCR gene therapy by MHC-restricted fratricide and TCR-mediated hematopoietic stem cell toxicity
por: Schendel, Dolores J., et al.
Publicado: (2013)

Monoubiquitination and Activity of the Paracaspase MALT1 Requires Glutamate 549 in the Dimerization Interface
por: Cabalzar, Katrin, et al.
Publicado: (2013)

Force Measurements of TCR/pMHC Recognition at T Cell Surface
por: Puech, Pierre-Henri, et al.
Publicado: (2011)

Genome-wide structural modelling of TCR-pMHC interactions
por: Liu, I-Hsin, et al.
Publicado: (2013)

TCR/pMHC Interaction: Phenotypic Model for an Unsolved Enigma
por: Gálvez, Jesús, et al.
Publicado: (2016)

Integrating Experiment and Theory to Understand TCR-pMHC Dynamics
por: Buckle, Ashley M., et al.
Publicado: (2018)

TCR‐induced alteration of primary MHC peptide anchor residue
por: Madura, Florian, et al.
Publicado: (2019)

Inherent reactivity of unselected TCR repertoires to peptide-MHC molecules
por: Krovi, S. Harsha, et al.
Publicado: (2019)

TCR Recognition of Peptide–MHC-I: Rule Makers and Breakers
por: Szeto, Christopher, et al.
Publicado: (2020)

Rapid screening of TCR-pMHC interactions by the YAMTAD system
por: Wang, Lihui, et al.
Publicado: (2022)

Information-Driven Docking for TCR-pMHC Complex Prediction
por: Peacock, Thomas, et al.
Publicado: (2021)

Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinity-increased CD8 T lymphocytes
por: Duong, Minh Ngoc, et al.
Publicado: (2019)

Immuno-Isolation of Pancreatic Islet Allografts Using Pegylated Nanotherapy Leads to Long-Term Normoglycemia in Full MHC Mismatch Recipient Mice
por: Dong, Huansheng, et al.
Publicado: (2012)

Regulatory T cells and co‐evolution of allele‐specific MHC recognition by the TCR
por: Steele, Edward J., et al.
Publicado: (2019)

Hybrid gMLP model for interaction prediction of MHC-peptide and TCR
por: Zhang, Lichao, et al.
Publicado: (2023)

Germline-Encoded TCR-MHC Contacts Promote TCR V Gene Bias in Umbilical Cord Blood T Cell Repertoire
por: Gao, Kai, et al.
Publicado: (2019)

Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma
por: Schaller, Julien, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_d0stj6nn1spfr7qep2cmi6pidm