Increased Musashi-2 and Decreased NUMB Protein Levels Observed in Human Colorectal Cancer are reverted to Normal Levels by ATRA-Induced Cell Differentiation

BACKGROUND: Musashi stem cell (SC) proteins (MSI-1 & MSI-2) are known to become over expressed during colorectal tumorigenesis in humans and mice. MSI-1 overexpression induces tumorigenesis through Notch activation via inactivation of NUMB. Previous studies also show that MSI-2 overexpression in...

Descripción completa

Detalles Bibliográficos
Autores principales: Opdenaker, Lynn M, Kowash, Ryan, Masters, Gabriel, Boman, Bruce M, Zhang, Tao, Modarai, Shirin R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517600/
https://www.ncbi.nlm.nih.gov/pubmed/32984754
http://dx.doi.org/10.33140/ijcrt/03/02/00003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517600/
https://www.ncbi.nlm.nih.gov/pubmed/32984754
http://dx.doi.org/10.33140/ijcrt/03/02/00003

Ejemplares similares