Design and Synthesis of Novel Nordihydroguaiaretic Acid (NDGA) Analogues as Potential FGFR1 Kinase Inhibitors With Anti-Gastric Activity and Chemosensitizing Effect

Aberrant fibroblast growth factor receptor-1 (FGFR1), a key driver promoting gastric cancer (GC) progression and chemo-resistance, has been increasingly recognized as a potential therapeutic target in GC. Hereon, we designed and synthesized a series of asymmetric analogues using Af23 and NDGA as lea...

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Detalles Bibliográficos
Autores principales: Chen, Qian, Zhu, Min, Xie, Jingwen, Dong, Zhaojun, Khushafah, Fatehi, Yun, Di, Fu, Weitao, Wang, Ledan, Wei, Tao, Liu, Zhiguo, Qiu, Peihong, Wu, Jianzhang, Li, Wulan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517944/
https://www.ncbi.nlm.nih.gov/pubmed/33041789
http://dx.doi.org/10.3389/fphar.2020.518068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517944/
https://www.ncbi.nlm.nih.gov/pubmed/33041789
http://dx.doi.org/10.3389/fphar.2020.518068

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