Cargando…

Design and Synthesis of Novel Nordihydroguaiaretic Acid (NDGA) Analogues as Potential FGFR1 Kinase Inhibitors With Anti-Gastric Activity and Chemosensitizing Effect

Aberrant fibroblast growth factor receptor-1 (FGFR1), a key driver promoting gastric cancer (GC) progression and chemo-resistance, has been increasingly recognized as a potential therapeutic target in GC. Hereon, we designed and synthesized a series of asymmetric analogues using Af23 and NDGA as lea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Qian, Zhu, Min, Xie, Jingwen, Dong, Zhaojun, Khushafah, Fatehi, Yun, Di, Fu, Weitao, Wang, Ledan, Wei, Tao, Liu, Zhiguo, Qiu, Peihong, Wu, Jianzhang, Li, Wulan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517944/ https://www.ncbi.nlm.nih.gov/pubmed/33041789 http://dx.doi.org/10.3389/fphar.2020.518068

Ejemplares similares

Nordihydroguaiaretic acid (NDGA) inhibits ritonavir-induced endothelial dysfunction in porcine pulmonary arteries
por: Lü, Jian-Ming, et al.
Publicado: (2011)

Long chain polyunsaturated fatty acids (LCPUFAs) and nordihydroguaiaretic acid (NDGA) modulate metabolic and inflammatory markers in a spontaneous type 2 diabetes mellitus model (Stillman Salgado rats)
por: Dain, Alejandro, et al.
Publicado: (2016)

Nordihydroguaiaretic Acid: From Herbal Medicine to Clinical Development for Cancer and Chronic Diseases
por: Manda, Gina, et al.
Publicado: (2020)

Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis
por: Zhang, Haiyan, et al.
Publicado: (2015)

Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents
por: Wang, Jiabing, et al.
Publicado: (2019)

Cyclized NDGA modifies dynamic α-synuclein monomers preventing aggregation and toxicity
por: Daniels, Malcolm J., et al.
Publicado: (2019)

Author correction to ‘Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents’ [Acta Pharmaceutica Sinica B 9 (2019) 335–350]
por: Wang, Jiabing, et al.
Publicado: (2022)

Stimulation of Melanogenesis by Nordihydroguaiaretic Acid in Human Melanoma Cells
por: Takekoshi, Susumu, et al.
Publicado: (2014)

Assessing Nordihydroguaiaretic Acid Therapeutic Effect for Glioblastoma Multiforme
por: Manciu, Felicia S., et al.
Publicado: (2022)

Compound 15c, a Novel Dual Inhibitor of EGFR(L858R/T790M) and FGFR1, Efficiently Overcomes Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance of Non-Small-Cell Lung Cancers
por: Chen, Gaozhi, et al.
Publicado: (2020)

The In Vitro and In Vivo Effect of Lipoxygenase Pathway Inhibitors Nordihydroguaiaretic Acid and Its Derivative Tetra-O-methyl Nordihydroguaiaretic Acid against Brucella abortus 544
por: Reyes, Alisha Wehdnesday Bernardo, et al.
Publicado: (2022)

A novel small molecule RK-019 inhibits FGFR2-amplification gastric cancer cell proliferation and induces apoptosis in vitro and in vivo
por: Zeng, Jun, et al.
Publicado: (2022)

Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer
por: Liu, Yanan, et al.
Publicado: (2021)

Effects of Celecoxib and Nordihydroguaiaretic Acid on Puromycin Aminonucleoside-Induced Nephrosis in the Rat
por: Lee, Dong Won, et al.
Publicado: (2009)

Opposing Effects of Indomethacin and Nordihydroguaiaretic Acid on Macrophage Function and Tumor Growth
por: Suzuki, Michihiro, et al.
Publicado: (1994)

β-Elemene: Mechanistic Studies on Cancer Cell Interaction and Its Chemosensitization Effect
por: Jiang, Ziyu, et al.
Publicado: (2017)

Temporospatial Expression of Fgfr1 and 2 During Lung Development, Homeostasis, and Regeneration
por: Yuan, Tingting, et al.
Publicado: (2020)

Editorial: Chemosensitizing effect of natural products against cancers: Applications in enhancing chemotherapy and immunotherapy
por: Roy, Nand K., et al.
Publicado: (2022)

Deficiency of endothelial FGFR1 alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice
por: Long, Yanrong, et al.
Publicado: (2022)

Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells
por: Seufferlein, T, et al.
Publicado: (2002)

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy
por: Tezil, Tugsan, et al.
Publicado: (2019)

In Vitro Antiviral Activity of Nordihydroguaiaretic Acid against SARS-CoV-2
por: Villalobos-Sánchez, Erendira, et al.
Publicado: (2023)

RAB39B as a Chemosensitivity-Related Biomarker for Diffuse Large B-Cell Lymphoma
por: Xu, Cong, et al.
Publicado: (2022)

Discovery and anti-cancer evaluation of two novel non-ATP-competitive FGFR1 inhibitors in non-small-cell lung cancer
por: Wu, Jianzhang, et al.
Publicado: (2015)

Knockdown lncRNA DLEU1 Inhibits Gliomas Progression and Promotes Temozolomide Chemosensitivity by Regulating Autophagy
por: Lv, Qiao-Li, et al.
Publicado: (2020)

Rational design, synthesis, and pharmacological characterisation of dicarbonyl curcuminoid analogues with improved stability against lung cancer via ROS and ER stress mediated cell apoptosis and pyroptosis
por: Wei, Tao, et al.
Publicado: (2022)

Microarray analysis of gene expression in liver, adipose tissue and skeletal muscle in response to chronic dietary administration of NDGA to high-fructose fed dyslipidemic rats
por: Zhang, Haiyan, et al.
Publicado: (2016)

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males
por: Harrison, David E, et al.
Publicado: (2014)

Effect of nordihydroguaiaretic acid on cell viability and glucose transport in human leukemic cell lines
por: Leon, David, et al.
Publicado: (2016)

Facile synthesis and nanoscale features of a nanostructured nordihydroguaiaretic acid analog for therapeutic applications
por: John, Geraldine Sandana Mala, et al.
Publicado: (2020)

Clinical pharmacology and pharmacogenetics of prostaglandin analogues in glaucoma
por: Zhou, Lin, et al.
Publicado: (2022)

Discovery of novel non-ATP competitive FGFR1 inhibitors and evaluation of their anti-tumor activity in non-small cell lung cancer in vitro and in vivo
por: Wu, Jianzhang, et al.
Publicado: (2014)

A Nudibranch Marine Extract Selectively Chemosensitizes Colorectal Cancer Cells by Inducing ROS-Mediated Endoplasmic Reticulum Stress
por: Ruiz-Torres, Verónica, et al.
Publicado: (2021)

Falcarindiol Enhances Cisplatin Chemosensitivity of Hepatocellular Carcinoma via Down-Regulating the STAT3-Modulated PTTG1 Pathway
por: Hong, Han, et al.
Publicado: (2021)

Peptibody Based on FGFR1-Binding Peptides From the FGF4 Sequence as a Cancer-Targeting Agent
por: Jendryczko, Karolina, et al.
Publicado: (2021)

Editorial: Erythropoietin and Its Analogues as Therapeutics for Neurological Diseases
por: Brines, Michael, et al.
Publicado: (2022)

Overexpression of miR-100 inhibits cell proliferation, migration, and chemosensitivity in human glioblastoma through FGFR3
por: Luan, Yongxin, et al.
Publicado: (2015)

Nordihydroguaiaretic Acid Attenuates the Oxidative Stress-Induced Decrease of CD33 Expression in Human Monocytes
por: Guzmán-Beltrán, Silvia, et al.
Publicado: (2013)

Nordihydroguaiaretic acid activates hTRPA1 and modulates behavioral responses to noxious cold in mice
por: Redmond, William John, et al.
Publicado: (2014)

Nordihydroguaiaretic acid impairs prostate cancer cell migration and tumor metastasis by suppressing neuropilin 1
por: Li, Xin, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_4ph0ope6pdo6784c4uojlj7mt3