Characterization of a single chain variable fragment of nivolumab that targets PD-1 and blocks PD-L1 binding

Activated T-cells express Programmed cell Death protein 1 (PD-1), a key immune checkpoint receptor. PD-1 functions primarily in peripheral tissues, where T cells may encounter tumor-derived immunosuppressive ligands. Monoclonal antibodies that disrupt the interaction between T-cell derived PD-1 and...

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Detalles Bibliográficos
Autores principales: Shin, Jong, Phelan, Paul J., Gjoerup, Ole, Bachovchin, William, Bullock, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518118/
https://www.ncbi.nlm.nih.gov/pubmed/32987122
http://dx.doi.org/10.1016/j.pep.2020.105766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518118/
https://www.ncbi.nlm.nih.gov/pubmed/32987122
http://dx.doi.org/10.1016/j.pep.2020.105766

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