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Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila

Akkermansia muciniphila is a mucin-degrading bacterium commonly found in the human gut that promotes a beneficial effect on health, likely based on the regulation of mucus thickness and gut barrier integrity, but also on the modulation of the immune system. In this work, we focus in OgpA from A. muc...

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Detalles Bibliográficos
Autores principales: Trastoy, Beatriz, Naegeli, Andreas, Anso, Itxaso, Sjögren, Jonathan, Guerin, Marcelo E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518263/
https://www.ncbi.nlm.nih.gov/pubmed/32973204
http://dx.doi.org/10.1038/s41467-020-18696-y