Sclerostin inhibits interleukin-1β-induced late stage chondrogenic differentiation through downregulation of Wnt/β-catenin signaling pathway

It is known that Wnt/β-catenin signaling induces endochondral ossification and plays a significant role in the pathophysiology of osteoarthritis (OA). Sclerostin is a potent inhibitor of the Wnt/β-catenin signaling pathway. This study investigated the role of sclerostin in the endochondral different...

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Detalles Bibliográficos
Autores principales: Miyatake, Kazuma, Kumagai, Ken, Imai, Sosuke, Yamaguchi, Yasuteru, Inaba, Yutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518574/
https://www.ncbi.nlm.nih.gov/pubmed/32976505
http://dx.doi.org/10.1371/journal.pone.0239651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518574/
https://www.ncbi.nlm.nih.gov/pubmed/32976505
http://dx.doi.org/10.1371/journal.pone.0239651

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