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Sclerostin inhibits interleukin-1β-induced late stage chondrogenic differentiation through downregulation of Wnt/β-catenin signaling pathway

It is known that Wnt/β-catenin signaling induces endochondral ossification and plays a significant role in the pathophysiology of osteoarthritis (OA). Sclerostin is a potent inhibitor of the Wnt/β-catenin signaling pathway. This study investigated the role of sclerostin in the endochondral different...

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Detalles Bibliográficos
Autores principales:	Miyatake, Kazuma, Kumagai, Ken, Imai, Sosuke, Yamaguchi, Yasuteru, Inaba, Yutaka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518574/ https://www.ncbi.nlm.nih.gov/pubmed/32976505 http://dx.doi.org/10.1371/journal.pone.0239651

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