ISG15 overexpression compensates the defect of Crimean-Congo hemorrhagic fever virus polymerase bearing a protease-inactive ovarian tumor domain

Crimean-Congo Hemorrhagic Fever virus (CCHFV; family Nairoviridae) is an extremely pathogenic member of the Bunyavirales order. Previous studies have shown that the N-terminal domain of the CCHFV polymerase (L) contains an ovarian tumor-type protease (OTU) domain with the capability to remove both u...

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Detalles Bibliográficos
Autores principales: Devignot, Stephanie, Kromer, Thilo, Mirazimi, Ali, Weber, Friedemann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518590/
https://www.ncbi.nlm.nih.gov/pubmed/32931521
http://dx.doi.org/10.1371/journal.pntd.0008610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518590/
https://www.ncbi.nlm.nih.gov/pubmed/32931521
http://dx.doi.org/10.1371/journal.pntd.0008610

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