Cargando…

Bone morphogenetic protein 7 promotes resistance to immunotherapy

Immunotherapies revolutionized cancer treatment by harnessing the immune system to target cancer cells. However, most patients are resistant to immunotherapies and the mechanisms underlying this resistant is still poorly understood. Here, we report that overexpression of BMP7, a member of the TGFB s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cortez, Maria Angelica, Masrorpour, Fatemeh, Ivan, Cristina, Zhang, Jie, Younes, Ahmed, Lu, Yue, Estecio, Marcos R, Barsoumian, Hampartsoum B., Menon, Hari, Caetano, Mauricio da Silva, Ramapriyan, Rishab, Schoenhals, Jonathan E., Wang, Xiaohong, Skoulidis, Ferdinandos, Wasley, Mark D., Calin, George, Hwu, Patrick, Welsh, James W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519103/ https://www.ncbi.nlm.nih.gov/pubmed/32973129 http://dx.doi.org/10.1038/s41467-020-18617-z

Ejemplares similares

Author Correction: Bone morphogenetic protein 7 promotes resistance to immunotherapy
por: Cortez, Maria Angelica, et al.
Publicado: (2020)

Response and outcomes after anti-CTLA4 versus anti-PD1 combined with stereotactic body radiation therapy for metastatic non-small cell lung cancer: retrospective analysis of two single-institution prospective trials
por: Chen, Dawei, et al.
Publicado: (2020)

Low-dose radiation treatment enhances systemic antitumor immune responses by overcoming the inhibitory stroma
por: Barsoumian, Hampartsoum B, et al.
Publicado: (2020)

Addition of TLR9 agonist immunotherapy to radiation improves systemic antitumor activity
por: Younes, Ahmed I., et al.
Publicado: (2020)

Bone morphogenetic proteins, activins, and growth and differentiation factors in tumor immunology and immunotherapy resistance
por: Ganjoo, Shonik, et al.
Publicado: (2022)

Anti-glucocorticoid-induced Tumor Necrosis Factor–Related Protein (GITR) Therapy Overcomes Radiation-Induced Treg Immunosuppression and Drives Abscopal Effects
por: Schoenhals, Jonathan E., et al.
Publicado: (2018)

Pulsed radiotherapy to mitigate high tumor burden and generate immune memory
por: Sezen, Duygu, et al.
Publicado: (2022)

Role of Radiation Therapy in Modulation of the Tumor Stroma and Microenvironment
por: Menon, Hari, et al.
Publicado: (2019)

The role of tumor metabolism in modulating T-Cell activity and in optimizing immunotherapy
por: Ganjoo, Shonik, et al.
Publicado: (2023)

Radiation Therapy Modulates Tumor Physical Characteristics to Reduce Intratumoral Pressure and Enhance Intratumoral Drug Delivery and Retention
por: Barsoumian, Hampartsoum B., et al.
Publicado: (2022)

A radioenhancing nanoparticle mediated immunoradiation improves survival and generates long-term antitumor immune memory in an anti-PD1-resistant murine lung cancer model
por: Hu, Yun, et al.
Publicado: (2021)

High Plus Low Dose Radiation Strategy in Combination with TIGIT and PD1 Blockade to Promote Systemic Antitumor Responses
por: Barsoumian, Hampartsoum B., et al.
Publicado: (2022)

Influence of low-dose radiation on abscopal responses in patients receiving high-dose radiation and immunotherapy
por: Menon, Hari, et al.
Publicado: (2019)

Radiation and Anti-Cancer Vaccines: A Winning Combination
por: Cadena, Alexandra, et al.
Publicado: (2018)

Combining a nanoparticle-mediated immunoradiotherapy with dual blockade of LAG3 and TIGIT improves the treatment efficacy in anti-PD1 resistant lung cancer
por: Hu, Yun, et al.
Publicado: (2022)

NLRP3 agonist enhances radiation-induced immune priming and promotes abscopal responses in anti-PD1 resistant model
por: Barsoumian, Hampartsoum B., et al.
Publicado: (2023)

Combination treatment with radiotherapy and a novel oxidative phosphorylation inhibitor overcomes PD-1 resistance and enhances antitumor immunity
por: Chen, Dawei, et al.
Publicado: (2020)

NLRP3 agonist enhances radiation-induced immune priming and promotes abscopal responses in anti-PD1 resistant model
por: Barsoumian, Hampartsoum B., et al.
Publicado: (2023)

Role of Mitochondria in Cancer Immune Evasion and Potential Therapeutic Approaches
por: Klein, Katherine, et al.
Publicado: (2020)

4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4(+)CD25(+)FoxP3(+) T Regulatory Cell Suppression
por: Barsoumian, Hampartsoum B., et al.
Publicado: (2016)

NBTXR3 improves the efficacy of immunoradiotherapy combining nonfucosylated anti-CTLA4 in an anti-PD1 resistant lung cancer model
por: Hu, Yun, et al.
Publicado: (2022)

Pulsed Radiation Therapy to Improve Systemic Control of Metastatic Cancer
por: He, Kewen, et al.
Publicado: (2021)

Novel Use of Low-Dose Radiotherapy to Modulate the Tumor Microenvironment of Liver Metastases
por: He, Kewen, et al.
Publicado: (2021)

Hereditary diffuse gastric cancer therapeutic roadmap: current and novel approaches in a nutshell
por: El Rami, Fadi E., et al.
Publicado: (2020)

Nanoparticle-enhanced proton beam immunoradiotherapy drives immune activation and durable tumor rejection
por: Hu, Yun, et al.
Publicado: (2023)

Pembrolizumab with or without radiation therapy for metastatic non-small cell lung cancer: a randomized phase I/II trial
por: Welsh, James, et al.
Publicado: (2020)

Tumor kinetics prior to treatment correlate with response to checkpoint inhibitors
por: Cadena, Alexandra P, et al.
Publicado: (2015)

Introduction to morphogenetic computing
por: Resconi, Germano, et al.
Publicado: (2017)

Morphogenetic roles of acetylcholine.
por: Lauder, J M, et al.
Publicado: (1999)

Interplay between bone morphogenetic proteins and cognate binding proteins in bone and cartilage development: noggin, chordin and DAN
por: Reddi, Hari A
Publicado: (2001)

Identification of KRAS(G12C) Mutations in Circulating Tumor DNA in Patients With Cancer
por: Thein, Kyaw Z., et al.
Publicado: (2022)

The Role of Antibody-Based Therapies in Neuro-Oncology
por: Ramapriyan, Rishab, et al.
Publicado: (2023)

Morphogenetically-Active Barrier Membrane for Guided Bone Regeneration, Based on Amorphous Polyphosphate
por: Wang, Xiaohong, et al.
Publicado: (2017)

Emergence: morphogenetic design strategies
por: Hensel, Michael, et al.
Publicado: (2004)

The Classic: Bone Morphogenetic Protein
por: Urist, Marshall R., et al.
Publicado: (2009)

Morphogenetic degeneracies in the actomyosin cortex
por: Naganathan, Sundar Ram, et al.
Publicado: (2018)

Patterning of morphogenetic anisotropy fields
por: Wang, Zihang, et al.
Publicado: (2023)

Bone morphogenetic protein-4 and bone morphogenetic protein receptors expressions in the adult rat eye
por: Maruyama-Koide, Yuka, et al.
Publicado: (2017)

Clinical validation of Guardant360 CDx as a blood-based companion diagnostic for sotorasib
por: Bauml, Joshua M., et al.
Publicado: (2022)

Lipid metabolism in tumor immunology and immunotherapy
por: Duong, Lisa K., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_8hn3a4mnh9rihbfsejerinalak