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Synaptic secretion from human natural killer cells is diverse and includes supramolecular attack particles

Natural killer (NK) cells form immune synapses to ascertain the state of health of cells they encounter. If a target cell triggers NK cell cytotoxicity, lytic granules containing proteins including perforin and granzyme B, are secreted into the synaptic cleft inducing target cell death. Secretion of...

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Detalles Bibliográficos
Autores principales: Ambrose, Ashley R., Hazime, Khodor S., Worboys, Jonathan D., Niembro-Vivanco, Olatz, Davis, Daniel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519227/
https://www.ncbi.nlm.nih.gov/pubmed/32900953
http://dx.doi.org/10.1073/pnas.2010274117