Dynamic structural order of a low-complexity domain facilitates assembly of intermediate filaments

The coiled-coil domains of intermediate filament (IF) proteins are flanked by regions of low sequence complexity. Whereas IF coiled-coil domains assume dimeric and tetrameric conformations on their own, maturation of eight tetramers into cylindrical IFs is dependent on either “head” or “tail” domain...

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Detalles Bibliográficos
Autores principales: Sysoev, Vasiliy O., Kato, Masato, Sutherland, Lillian, Hu, Rong, McKnight, Steven L., Murray, Dylan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519307/
https://www.ncbi.nlm.nih.gov/pubmed/32907935
http://dx.doi.org/10.1073/pnas.2010000117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519307/
https://www.ncbi.nlm.nih.gov/pubmed/32907935
http://dx.doi.org/10.1073/pnas.2010000117

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