TDP-43 mediated blood-brain barrier permeability and leukocyte infiltration promote neurodegeneration in a low-grade systemic inflammation mouse model

BACKGROUND: Neuronal cytoplasmic inclusions containing TAR DNA-binding protein 43 (TDP-43) are a neuropathological feature of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer’s Disease (AD). Emerging evidence also indicat...

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Detalles Bibliográficos
Autores principales: Zamudio, Frank, Loon, Anjanet R., Smeltzer, Shayna, Benyamine, Khawla, Navalpur Shanmugam, Nanda K., Stewart, Nicholas J. F., Lee, Daniel C., Nash, Kevin, Selenica, Maj-Linda B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519496/
https://www.ncbi.nlm.nih.gov/pubmed/32979923
http://dx.doi.org/10.1186/s12974-020-01952-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519496/
https://www.ncbi.nlm.nih.gov/pubmed/32979923
http://dx.doi.org/10.1186/s12974-020-01952-9

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