The therapeutic effect of the BRD4-degrading PROTAC A1874 in human colon cancer cells

A1874 is a novel BRD4-degrading proteolysis targeting chimera (PROTAC). In primary colon cancer cells and established HCT116 cells, A1874 potently inhibited cell viability, proliferation, cell cycle progression, as well as cell migration and invasion. The BRD4-degrading PROTAC was able to induce cas...

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Detalles Bibliográficos
Autores principales: Qin, An-cheng, Jin, Hua, Song, Yu, Gao, Yun, Chen, Yi-Fan, Zhou, Li-na, Wang, Shu-sheng, Lu, Xing-sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519683/
https://www.ncbi.nlm.nih.gov/pubmed/32978368
http://dx.doi.org/10.1038/s41419-020-03015-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519683/
https://www.ncbi.nlm.nih.gov/pubmed/32978368
http://dx.doi.org/10.1038/s41419-020-03015-6

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