Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice

Loss-of-function mutations in TANK-binding kinase 1 cause genetic amyotrophic lateral sclerosis and frontotemporal dementia. Consistent with incomplete penetrance in humans, haploinsufficiency of TANK-binding kinase 1 did not cause motor symptoms in mice up to 7 months of age in a previous study. Ag...

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Detalles Bibliográficos
Autores principales: Bruno, Clara, Sieverding, Kirsten, Freischmidt, Axel, Satoh, Takashi, Walther, Paul, Mayer, B, Ludolph, Albert C, Akira, Shizuo, Yilmazer-Hanke, Deniz, Danzer, Karin M, Lobsiger, Christian S, Brenner, David, Weishaupt, Jochen H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519725/
https://www.ncbi.nlm.nih.gov/pubmed/33005894
http://dx.doi.org/10.1093/braincomms/fcaa133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519725/
https://www.ncbi.nlm.nih.gov/pubmed/33005894
http://dx.doi.org/10.1093/braincomms/fcaa133

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